Enables mRNA (nucleoside-2'-O-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CMTR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CMTR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CMTR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:71,176,306–71,177,119 | 112.7 kb | Distal (>10kb) Multiome | 101 | |
| chr16:71,230,392–71,230,982 | 58.7 kb | Distal (>10kb) Multiome | 194 | |
| chr16:71,288,904–71,289,782 | 19 bp | At TSS Multiome | 1067 | |
| chr16:71,358,510–71,359,053 | 69.3 kb | Distal (>10kb) Multiome | 387 | |
| chr16:71,412,167–71,413,209 | 123.3 kb | Distal (>10kb) Multiome | 349 | |
| chr16:71,425,887–71,427,162 | 137.1 kb | Distal (>10kb) Multiome | 924 | |
| chr16:71,441,362–71,442,080 | 152.3 kb | Distal (>10kb) Multiome | 232 | |
| chr16:71,461,920–71,462,398 | 172.8 kb | Distal (>10kb) Multiome | 944 | |
| chr16:71,484,066–71,484,742 | 195.0 kb | Distal (>10kb) Multiome | 801 | |
| chr16:71,526,040–71,526,860 | 237.0 kb | Distal (>10kb) Multiome | 294 | |
| chr16:71,564,628–71,565,649 | 275.7 kb | Distal (>10kb) Multiome | 792 |
Genomic view of the CMTR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.