The protein encoded by this gene is a membrane protein whose overexpression in cisplatin-sensitive cells causes apoptosis. Polymorphisms in this gene have been reported to increase susceptibility to several cancers, including lung, pancreatic, and breast cancers. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for CLPTM1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLPTM1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLPTM1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:1,102,030–1,102,780 | 242.7 kb | Distal (>10kb) Multiome | 207 | |
| chr5:1,111,233–1,112,367 | 233.1 kb | Distal (>10kb) Multiome | 516 | |
| chr5:1,294,274–1,295,675 | 50.0 kb | Distal (>10kb) Multiome | 415 | |
| chr5:1,344,394–1,345,745 | 15 bp | At TSS Multiome | 652 | |
| chr5:1,385,584–1,386,611 | 40.9 kb | Distal (>10kb) Multiome | 420 | |
| chr5:1,444,671–1,446,554 | 100.4 kb | Distal (>10kb) Multiome | 180 | |
| chr5:1,523,066–1,524,710 | 179.0 kb | Distal (>10kb) Multiome | 630 | |
| chr5:1,593,846–1,595,021 | 249.5 kb | Distal (>10kb) Multiome | 682 | |
| chr5:1,633,700–1,634,325 | 288.9 kb | Distal (>10kb) Multiome | 745 | |
| chr5:1,644,948–1,645,570 | 300.1 kb | Distal (>10kb) Multiome | 437 |
Genomic view of the CLPTM1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.