Predicted to enable clathrin binding activity. Predicted to be involved in intracellular transport. Predicted to be part of AP-1 adaptor complex. Predicted to be active in trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CLBA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLBA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLBA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:104,689,023–104,690,058 | 296.3 kb | Distal (>10kb) Multiome | 571 | |
| chr14:104,708,563–104,709,104 | 277.0 kb | Distal (>10kb) Multiome | 300 | |
| chr14:104,723,348–104,724,675 | 261.7 kb | Distal (>10kb) Multiome | 710 | |
| chr14:104,752,085–104,753,760 | 232.9 kb | Distal (>10kb) Multiome | 924 | |
| chr14:104,768,378–104,769,330 | 217.0 kb | Distal (>10kb) Multiome | 614 | |
| chr14:104,793,970–104,794,513 | 191.5 kb | Distal (>10kb) Multiome | 302 | |
| chr14:104,795,078–104,796,304 | 190.0 kb | Distal (>10kb) Multiome | 456 | |
| chr14:104,799,612–104,801,541 | 186.1 kb | Distal (>10kb) Multiome | 749 | |
| chr14:104,815,517–104,816,820 | 169.7 kb | Distal (>10kb) Multiome | 1064 | |
| chr14:104,825,631–104,828,095 | 157.9 kb | Distal (>10kb) Multiome | 653 | |
| chr14:104,863,847–104,866,207 | 121.5 kb | Distal (>10kb) Multiome | 743 | |
| chr14:104,932,604–104,933,678 | 52.3 kb | Distal (>10kb) Multiome | 498 | |
| chr14:104,967,607–104,968,024 | 17.9 kb | Distal (>10kb) Multiome | 196 | |
| chr14:104,975,803–104,976,561 | 9.6 kb | Proximal (<10kb) Multiome | 394 | |
| chr14:104,977,531–104,979,147 | 7.3 kb | Proximal (<10kb) Multiome | 387 | |
| chr14:104,985,398–104,986,377 | 35 bp | At TSS Multiome | 518 | |
| chr14:105,020,271–105,022,072 | 35.5 kb | Distal (>10kb) Multiome | 813 | |
| chr14:105,045,704–105,046,235 | 60.1 kb | Distal (>10kb) Multiome | 635 | |
| chr14:105,086,627–105,087,884 | 101.2 kb | Distal (>10kb) Multiome | 590 | |
| chr14:105,090,382–105,091,009 | 104.9 kb | Distal (>10kb) Multiome | 375 | |
| chr14:105,092,908–105,094,307 | 108.1 kb | Distal (>10kb) Multiome | 495 | |
| chr14:105,167,331–105,169,463 | 183.3 kb | Distal (>10kb) Multiome | 496 | |
| chr14:105,180,714–105,181,828 | 195.5 kb | Distal (>10kb) Multiome | 392 | |
| chr14:105,248,175–105,249,386 | 262.8 kb | Distal (>10kb) Multiome | 403 |
Genomic view of the CLBA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.