The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for CITED4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CITED4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CITED4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:40,665,223–40,666,079 | 196.7 kb | Distal (>10kb) Multiome | 465 | |
| chr1:40,691,236–40,692,758 | 170.6 kb | Distal (>10kb) Multiome | 1088 | |
| chr1:40,708,827–40,709,450 | 153.2 kb | Distal (>10kb) Multiome | 526 | |
| chr1:40,783,386–40,784,649 | 78.5 kb | Distal (>10kb) Multiome | 448 | |
| chr1:40,802,183–40,803,007 | 59.8 kb | Distal (>10kb) Multiome | 455 | |
| chr1:40,818,171–40,819,026 | 43.6 kb | Distal (>10kb) Multiome | 236 | |
| chr1:40,861,144–40,862,924 | 104 bp | At TSS Multiome | 724 | |
| chr1:40,863,635–40,864,299 | 1.3 kb | Proximal (<10kb) | 331 | |
| chr1:40,952,369–40,952,943 | 90.3 kb | Distal (>10kb) Multiome | 442 | |
| chr1:40,978,861–40,980,635 | 117.4 kb | Distal (>10kb) Multiome | 809 | |
| chr1:41,021,596–41,022,211 | 159.6 kb | Distal (>10kb) Multiome | 181 |
Genomic view of the CITED4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.