CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and oxidative phosphorylation (Wiley et al., 2007 [PubMed 17376863]).[supplied by OMIM, Apr 2008]
Transcription factors with Perturb-seq knockdown data for CISD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CISD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CISD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:38,453,611–38,454,219 | 276.5 kb | Distal (>10kb) Multiome | 168 | |
| chr17:38,509,961–38,510,926 | 219.8 kb | Distal (>10kb) Multiome | 409 | |
| chr17:38,558,106–38,558,652 | 172.0 kb | Distal (>10kb) Multiome | 631 | |
| chr17:38,559,205–38,559,900 | 170.7 kb | Distal (>10kb) Multiome | 598 | |
| chr17:38,572,553–38,573,232 | 157.4 kb | Distal (>10kb) Multiome | 231 | |
| chr17:38,604,448–38,605,250 | 125.4 kb | Distal (>10kb) Multiome HiCAR | 375 | |
| chr17:38,605,359–38,606,888 | 123.9 kb | Distal (>10kb) Multiome | 781 | |
| chr17:38,609,172–38,610,061 | 120.7 kb | Distal (>10kb) Multiome HiCAR | 229 | |
| chr17:38,673,658–38,675,315 | 55.4 kb | Distal (>10kb) Multiome | 847 | |
| chr17:38,701,857–38,703,072 | 28.0 kb | Distal (>10kb) Multiome | 907 | |
| chr17:38,703,568–38,704,668 | 26.4 kb | Distal (>10kb) Multiome | 955 | |
| chr17:38,704,725–38,707,220 | 25.0 kb | Distal (>10kb) Multiome | 784 | |
| chr17:38,718,492–38,719,127 | 11.6 kb | Distal (>10kb) Multiome | 268 | |
| chr17:38,719,228–38,720,635 | 10.1 kb | Distal (>10kb) Multiome | 290 | |
| chr17:38,729,824–38,730,713 | 120 bp | At TSS Multiome | 794 | |
| chr17:38,747,498–38,750,334 | 19.5 kb | Distal (>10kb) Multiome | 914 | |
| chr17:38,751,747–38,753,201 | 21.4 kb | Distal (>10kb) Multiome | 986 | |
| chr17:38,789,155–38,789,604 | 59.1 kb | Distal (>10kb) Multiome | 144 | |
| chr17:38,798,912–38,800,293 | 69.6 kb | Distal (>10kb) Multiome | 966 | |
| chr17:38,824,673–38,825,720 | 95.0 kb | Distal (>10kb) Multiome | 978 | |
| chr17:38,853,382–38,854,144 | 123.4 kb | Distal (>10kb) Multiome | 1047 | |
| chr17:38,867,391–38,868,381 | 137.4 kb | Distal (>10kb) Multiome | 640 | |
| chr17:38,869,253–38,871,194 | 139.5 kb | Distal (>10kb) Multiome | 1074 | |
| chr17:38,900,769–38,901,637 | 171.0 kb | Distal (>10kb) Multiome | 370 | |
| chr17:38,967,321–38,967,861 | 237.2 kb | Distal (>10kb) Multiome | 219 | |
| chr17:39,011,896–39,012,455 | 281.8 kb | Distal (>10kb) Multiome | 81 |
Genomic view of the CISD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.