Transcription factors with Perturb-seq knockdown data for CIBAR1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CIBAR1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CIBAR1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:93,693,728–93,694,359 | 6.1 kb | Proximal (<10kb) | 193 | |
| chr8:93,696,294–93,696,444 | 4.0 kb | Proximal (<10kb) | 38 | |
| chr8:93,696,568–93,696,796 | 3.6 kb | Proximal (<10kb) | 60 | |
| chr8:93,698,442–93,698,810 | 1.6 kb | Proximal (<10kb) | 133 | |
| chr8:93,699,869–93,701,509 | at TSS | At TSS | 609 |
Genomic view of the CIBAR1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.