Involved in chromosome segregation and protein maturation. Located in cytosol; nucleoplasm; and spindle. Part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CIAO2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CIAO2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CIAO2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:66,695,775–66,697,411 | 237.5 kb | Distal (>10kb) Multiome | 714 | |
| chr16:66,751,110–66,752,176 | 182.6 kb | Distal (>10kb) Multiome | 734 | |
| chr16:66,830,425–66,831,324 | 103.5 kb | Distal (>10kb) Multiome | 934 | |
| chr16:66,844,097–66,844,861 | 90.0 kb | Distal (>10kb) Multiome | 211 | |
| chr16:66,872,965–66,873,714 | 61.1 kb | Distal (>10kb) Multiome | 836 | |
| chr16:66,880,003–66,881,270 | 53.9 kb | Distal (>10kb) Multiome | 1020 | |
| chr16:66,924,739–66,925,515 | 9.3 kb | Proximal (<10kb) Multiome | 395 | |
| chr16:66,933,957–66,934,849 | 42 bp | At TSS Multiome | 931 | |
| chr16:67,000,412–67,001,423 | 66.6 kb | Distal (>10kb) Multiome | 270 | |
| chr16:67,013,778–67,014,584 | 79.7 kb | Distal (>10kb) Multiome | 594 | |
| chr16:67,017,916–67,018,379 | 83.7 kb | Distal (>10kb) Multiome | 530 | |
| chr16:67,028,567–67,029,938 | 94.6 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:67,109,102–67,110,434 | 175.4 kb | Distal (>10kb) Multiome | 895 | |
| chr16:67,149,282–67,151,406 | 216.3 kb | Distal (>10kb) Multiome | 693 | |
| chr16:67,154,687–67,155,820 | 221.1 kb | Distal (>10kb) Multiome | 593 | |
| chr16:67,160,628–67,161,206 | 226.6 kb | Distal (>10kb) Multiome | 524 | |
| chr16:67,162,969–67,163,815 | 229.0 kb | Distal (>10kb) Multiome | 238 | |
| chr16:67,169,105–67,171,287 | 235.2 kb | Distal (>10kb) Multiome | 813 | |
| chr16:67,173,849–67,174,861 | 239.9 kb | Distal (>10kb) Multiome | 809 | |
| chr16:67,177,863–67,178,664 | 243.9 kb | Distal (>10kb) Multiome | 544 | |
| chr16:67,183,333–67,184,856 | 249.5 kb | Distal (>10kb) Multiome HiCAR | 886 | |
| chr16:67,185,256–67,185,693 | 251.2 kb | Distal (>10kb) Multiome HiCAR | 740 | |
| chr16:67,191,949–67,192,449 | 257.7 kb | Distal (>10kb) Multiome | 781 | |
| chr16:67,198,940–67,200,211 | 265.3 kb | Distal (>10kb) Multiome | 325 | |
| chr16:67,226,487–67,227,575 | 292.6 kb | Distal (>10kb) Multiome | 909 |
Genomic view of the CIAO2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.