This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine) 6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of sulfate groups to distinct hydroxyl and amino groups of carbohydrates. The encoded protein catalyzes the sulfation of 6-hydroxyl group of GalNAc in chondroitin. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for CHST7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHST7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHST7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:46,446,683–46,447,587 | 126.6 kb | Distal (>10kb) Multiome | 537 | |
| chrX:46,573,341–46,574,623 | 27 bp | At TSS Multiome | 500 | |
| chrX:46,575,014–46,575,319 | 1.2 kb | Proximal (<10kb) | 168 | |
| chrX:46,758,820–46,759,807 | 185.5 kb | Distal (>10kb) Multiome | 494 | |
| chrX:46,836,621–46,837,502 | 263.1 kb | Distal (>10kb) Multiome | 606 |
Genomic view of the CHST7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.