This gene encodes an enzyme which catalyzes the sulfation of chondroitin, a proteoglycan found in the extracellular matrix and most cells which is involved in cell migration and differentiation. Mutations in this gene are associated with spondylepiphyseal dysplasia and humerospinal dysostosis. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for CHST3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHST3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHST3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:71,773,303–71,773,917 | 190.8 kb | Distal (>10kb) Multiome | 524 | |
| chr10:71,850,725–71,851,685 | 113.1 kb | Distal (>10kb) Multiome | 974 | |
| chr10:71,963,568–71,965,093 | 11 bp | At TSS Multiome | 614 | |
| chr10:72,215,518–72,216,511 | 251.7 kb | Distal (>10kb) Multiome | 971 | |
| chr10:72,254,948–72,255,560 | 290.8 kb | Distal (>10kb) Multiome | 585 | |
| chr10:72,259,944–72,262,216 | 296.5 kb | Distal (>10kb) Multiome | 1074 |
Genomic view of the CHST3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.