This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for CHST14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHST14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHST14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:40,323,099–40,324,127 | 147.5 kb | Distal (>10kb) Multiome | 737 | |
| chr15:40,357,707–40,358,772 | 112.8 kb | Distal (>10kb) Multiome | 515 | |
| chr15:40,367,875–40,368,398 | 102.8 kb | Distal (>10kb) Multiome | 846 | |
| chr15:40,405,523–40,406,103 | 65.3 kb | Distal (>10kb) Multiome | 672 | |
| chr15:40,440,664–40,441,222 | 30.1 kb | Distal (>10kb) Multiome | 440 | |
| chr15:40,470,654–40,471,315 | 5 bp | At TSS Multiome | 463 | |
| chr15:40,511,458–40,512,083 | 40.8 kb | Distal (>10kb) Multiome | 646 | |
| chr15:40,593,777–40,594,776 | 123.1 kb | Distal (>10kb) Multiome | 899 | |
| chr15:40,694,639–40,695,262 | 224.1 kb | Distal (>10kb) Multiome | 831 | |
| chr15:40,754,834–40,755,729 | 284.3 kb | Distal (>10kb) Multiome | 816 | |
| chr15:40,763,848–40,764,563 | 293.1 kb | Distal (>10kb) Multiome | 799 |
Genomic view of the CHST14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.