This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CHP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:40,941,651–40,942,174 | 289.3 kb | Distal (>10kb) Multiome | 643 | |
| chr15:40,952,899–40,953,683 | 277.9 kb | Distal (>10kb) Multiome | 618 | |
| chr15:41,115,645–41,116,753 | 114.8 kb | Distal (>10kb) Multiome | 909 | |
| chr15:41,230,581–41,231,535 | 208 bp | At TSS Multiome | 1063 | |
| chr15:41,283,739–41,284,308 | 52.7 kb | Distal (>10kb) Multiome | 798 | |
| chr15:41,332,102–41,333,206 | 101.4 kb | Distal (>10kb) Multiome | 883 | |
| chr15:41,416,690–41,417,765 | 185.8 kb | Distal (>10kb) Multiome | 734 | |
| chr15:41,493,120–41,493,918 | 262.4 kb | Distal (>10kb) Multiome | 692 |
Genomic view of the CHP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.