This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for CHMP6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHMP6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHMP6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:80,833,089–80,833,581 | 158.5 kb | Distal (>10kb) Multiome | 572 | |
| chr17:80,981,166–80,981,777 | 10.4 kb | Distal (>10kb) Multiome | 249 | |
| chr17:80,989,059–80,989,301 | 2.5 kb | Proximal (<10kb) | 471 | |
| chr17:80,991,699–80,992,263 | 103 bp | At TSS Multiome | 639 | |
| chr17:81,033,927–81,036,743 | 43.2 kb | Distal (>10kb) Multiome | 822 | |
| chr17:81,101,596–81,102,059 | 110.1 kb | Distal (>10kb) Multiome | 815 | |
| chr17:81,222,360–81,223,690 | 231.3 kb | Distal (>10kb) Multiome | 861 | |
| chr17:81,238,602–81,239,760 | 247.3 kb | Distal (>10kb) Multiome | 811 |
Genomic view of the CHMP6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.