CHMP4A
charged multivesicular body protein 4A | HSPC134, Snf7-1, VPS32A, hSnf7-1, C14orf123

CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Member of: DE-1
Biological processes 81 terms
ATPase binding (GO:0051117)ESCRT III complex (GO:0000815)ESCRT III complex (GO:0000815)ESCRT III complex (GO:0000815)amphisome membrane (GO:1904930)amphisome membrane (GO:1904930)autophagosome maturation (GO:0097352)autophagosome maturation (GO:0097352)autophagosome membrane (GO:0000421)autophagy (GO:0006914)cytoplasm (GO:0005737)cytoplasmic side of plasma membrane (GO:0009898)cytoplasmic side of plasma membrane (GO:0009898)cytoplasmic vesicle membrane (GO:0030659)cytosol (GO:0005829)endosome (GO:0005768)identical protein binding (GO:0042802)kinetochore (GO:0000776)kinetochore (GO:0000776)kinetochore microtubule (GO:0005828)kinetochore microtubule (GO:0005828)late endosome membrane (GO:0031902)late endosome to lysosome transport (GO:1902774)late endosome to lysosome transport (GO:1902774)late endosome to vacuole transport via multivesicular body sorting pathway (GO:0032511)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)macroautophagy (GO:0016236)membrane coat (GO:0030117)membrane fission (GO:0090148)membrane invagination (GO:0010324)midbody (GO:0030496)midbody (GO:0030496)midbody abscission (GO:0061952)midbody abscission (GO:0061952)mitotic metaphase chromosome alignment (GO:0007080)mitotic metaphase chromosome alignment (GO:0007080)multivesicular body (GO:0005771)multivesicular body assembly (GO:0036258)multivesicular body assembly (GO:0036258)multivesicular body assembly (GO:0036258)multivesicular body membrane (GO:0032585)multivesicular body membrane (GO:0032585)multivesicular body sorting pathway (GO:0071985)multivesicular body sorting pathway (GO:0071985)multivesicular body sorting pathway (GO:0071985)multivesicular body-lysosome fusion (GO:0061763)nervous system process (GO:0050877)nuclear envelope (GO:0005635)nuclear membrane reassembly (GO:0031468)nuclear membrane reassembly (GO:0031468)nuclear membrane reassembly (GO:0031468)nuclear pore (GO:0005643)nucleus (GO:0005634)nucleus organization (GO:0006997)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane repair (GO:0001778)plasma membrane repair (GO:0001778)plasma membrane tubulation (GO:0097320)plasma membrane tubulation (GO:0097320)post-translational protein targeting to endoplasmic reticulum membrane (GO:0006620)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)protein polymerization (GO:0051258)regulation of mitotic spindle assembly (GO:1901673)regulation of mitotic spindle assembly (GO:1901673)ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162)ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162)vacuolar transport (GO:0007034)vesicle budding from membrane (GO:0006900)vesicle budding from membrane (GO:0006900)vesicle budding from membrane (GO:0006900)vesicle fusion with vacuole (GO:0051469)viral budding from plasma membrane (GO:0046761)viral budding from plasma membrane (GO:0046761)viral budding via host ESCRT complex (GO:0039702)viral budding via host ESCRT complex (GO:0039702)viral budding via host ESCRT complex (GO:0039702)viral budding via host ESCRT complex (GO:0039702)
Expression (TPM)
CHMP4A — as a Regulated Gene

TFs regulating CHMP4A 0 TFs

Transcription factors with Perturb-seq knockdown data for CHMP4A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHMP4A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CHMP4A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHMP4A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:23,953,479–23,954,293 259.6 kb Distal (>10kb) Multiome 897
chr14:23,988,469–23,989,172 224.6 kb Distal (>10kb) Multiome 439
chr14:24,036,218–24,036,993 176.9 kb Distal (>10kb) Multiome 627
chr14:24,051,239–24,052,875 161.5 kb Distal (>10kb) Multiome 821
chr14:24,080,914–24,082,038 132.0 kb Distal (>10kb) Multiome 706
chr14:24,093,491–24,095,115 119.2 kb Distal (>10kb) Multiome 990
chr14:24,113,681–24,115,917 98.5 kb Distal (>10kb) Multiome 1166
chr14:24,135,549–24,136,884 77.4 kb Distal (>10kb) Multiome 778
chr14:24,140,526–24,142,331 71.7 kb Distal (>10kb) Multiome 1034
chr14:24,146,204–24,148,108 66.6 kb Distal (>10kb) Multiome 918
chr14:24,160,877–24,161,762 52.2 kb Distal (>10kb) Multiome 970
chr14:24,171,489–24,172,698 41.6 kb Distal (>10kb) Multiome 365
chr14:24,188,229–24,189,111 24.6 kb Distal (>10kb) Multiome 1074
chr14:24,195,072–24,196,365 17.9 kb Distal (>10kb) Multiome 1059
chr14:24,212,871–24,213,884 23 bp At TSS Multiome 1036
chr14:24,215,523–24,216,241 2.6 kb Proximal (<10kb) Multiome 955
chr14:24,231,706–24,233,147 19.1 kb Distal (>10kb) Multiome 1027
chr14:24,241,845–24,243,572 29.2 kb Distal (>10kb) Multiome 1077
chr14:24,270,770–24,271,924 58.0 kb Distal (>10kb) Multiome 1089
chr14:24,299,120–24,300,273 86.3 kb Distal (>10kb) Multiome 892
chr14:24,315,948–24,316,753 102.9 kb Distal (>10kb) Multiome 736
chr14:24,332,251–24,333,127 119.1 kb Distal (>10kb) Multiome 740
chr14:24,365,652–24,366,243 152.3 kb Distal (>10kb) Multiome 668
chr14:24,366,594–24,369,358 153.8 kb Distal (>10kb) Multiome 921
chr14:24,388,547–24,389,510 175.5 kb Distal (>10kb) Multiome 161
chr14:24,398,424–24,399,423 185.5 kb Distal (>10kb) Multiome 354
chr14:24,429,597–24,431,070 216.7 kb Distal (>10kb) Multiome 903
chr14:24,431,554–24,432,205 218.5 kb Distal (>10kb) Multiome 604
chr14:24,441,935–24,443,373 229.2 kb Distal (>10kb) Multiome 1072
chr14:24,481,599–24,482,121 268.4 kb Distal (>10kb) Multiome 593

Genome Browser

Genomic view of the CHMP4A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:23,943,479 – 24,492,121
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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