This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for CHMP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHMP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHMP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:86,336,997–86,338,159 | 225.8 kb | Distal (>10kb) Multiome | 267 | |
| chr2:86,368,200–86,368,804 | 194.9 kb | Distal (>10kb) Multiome | 227 | |
| chr2:86,440,468–86,442,936 | 122.3 kb | Distal (>10kb) Multiome | 1229 | |
| chr2:86,562,703–86,563,941 | 113 bp | At TSS Multiome | 1017 | |
| chr2:86,622,458–86,624,092 | 60.4 kb | Distal (>10kb) Multiome | 913 | |
| chr2:86,719,886–86,720,543 | 156.8 kb | Distal (>10kb) Multiome | 245 | |
| chr2:86,785,940–86,786,595 | 222.9 kb | Distal (>10kb) Multiome | 161 | |
| chr2:86,807,228–86,809,045 | 244.4 kb | Distal (>10kb) Multiome | 827 |
Genomic view of the CHMP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.