This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for CHD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:41,339,588–41,341,431 | 277.7 kb | Distal (>10kb) Multiome | 904 | |
| chr20:41,365,890–41,367,375 | 251.5 kb | Distal (>10kb) Multiome | 273 | |
| chr20:41,617,502–41,619,268 | 204 bp | At TSS Multiome | 758 | |
| chr20:41,692,587–41,693,817 | 74.7 kb | Distal (>10kb) Multiome | 1051 | |
| chr20:43,457,127–43,458,915 | 1839.4 kb | Distal (>10kb) Multiome HiCAR | 1116 |
Genomic view of the CHD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.