Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of cell growth. Located in endoplasmic reticulum and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CGRRF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CGRRF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CGRRF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:54,291,237–54,292,121 | 218.2 kb | Distal (>10kb) Multiome | 321 | |
| chr14:54,361,880–54,362,724 | 147.5 kb | Distal (>10kb) Multiome | 146 | |
| chr14:54,366,777–54,367,506 | 142.8 kb | Distal (>10kb) Multiome | 393 | |
| chr14:54,396,464–54,397,605 | 112.9 kb | Distal (>10kb) Multiome | 808 | |
| chr14:54,440,764–54,441,825 | 68.5 kb | Distal (>10kb) Multiome | 860 | |
| chr14:54,472,369–54,472,855 | 37.2 kb | Distal (>10kb) Multiome | 154 | |
| chr14:54,488,387–54,489,472 | 20.9 kb | Distal (>10kb) Multiome | 922 | |
| chr14:54,509,366–54,510,519 | 7 bp | At TSS Multiome | 801 | |
| chr14:54,564,898–54,567,596 | 55.5 kb | Distal (>10kb) Multiome | 963 | |
| chr14:54,567,716–54,568,327 | 58.3 kb | Distal (>10kb) Multiome | 296 | |
| chr14:54,773,202–54,773,766 | 263.5 kb | Distal (>10kb) Multiome | 548 | |
| chr14:54,805,654–54,806,307 | 296.2 kb | Distal (>10kb) Multiome | 376 |
Genomic view of the CGRRF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.