CGAS
cyclic GMP-AMP synthase | D4, h-cGAS, C6orf150, MB21D1

Enables several functions, including 2',3'-cyclic GMP-AMP synthase activity; molecular condensate scaffold activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including intracellular signal transduction; paracrine signaling; and regulation of defense response. Located in nuclear body; plasma membrane; and site of double-strand break. Is active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 75 terms
2',3'-cyclic GMP-AMP synthase activity (GO:0061501)2',3'-cyclic GMP-AMP synthase activity (GO:0061501)2',3'-cyclic GMP-AMP synthase activity (GO:0061501)2',3'-cyclic GMP-AMP synthase activity (GO:0061501)2',3'-cyclic GMP-AMP synthase activity (GO:0061501)DNA binding (GO:0003677)DNA binding (GO:0003677)DNA damage response (GO:0006974)DNA damage response (GO:0006974)activation of innate immune response (GO:0002218)activation of innate immune response (GO:0002218)activation of innate immune response (GO:0002218)activation of innate immune response (GO:0002218)cGAS/STING signaling pathway (GO:0140896)cGAS/STING signaling pathway (GO:0140896)cGAS/STING signaling pathway (GO:0140896)cellular response to exogenous dsRNA (GO:0071360)cellular response to exogenous dsRNA (GO:0071360)chromatin binding (GO:0003682)chromatin binding (GO:0003682)chromatin binding (GO:0003682)chromosome (GO:0005694)cytoplasm (GO:0005737)cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)defense response to virus (GO:0051607)defense response to virus (GO:0051607)double-stranded DNA binding (GO:0003690)double-stranded DNA binding (GO:0003690)double-stranded DNA binding (GO:0003690)double-stranded DNA binding (GO:0003690)identical protein binding (GO:0042802)molecular condensate scaffold activity (GO:0140693)molecular condensate scaffold activity (GO:0140693)negative regulation of DNA repair (GO:0045738)negative regulation of double-strand break repair via homologous recombination (GO:2000042)negative regulation of double-strand break repair via homologous recombination (GO:2000042)negative regulation of double-strand break repair via homologous recombination (GO:2000042)nuclear body (GO:0016604)nucleoplasm (GO:0005654)nucleosome binding (GO:0031491)nucleosome binding (GO:0031491)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)paracrine signaling (GO:0038001)paracrine signaling (GO:0038001)paracrine signaling (GO:0038001)pattern recognition receptor signaling pathway (GO:0002221)phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)plasma membrane (GO:0005886)plasma membrane (GO:0005886)poly-ADP-D-ribose modification-dependent protein binding (GO:0160004)poly-ADP-D-ribose modification-dependent protein binding (GO:0160004)positive regulation of cellular senescence (GO:2000774)positive regulation of cellular senescence (GO:2000774)positive regulation of defense response to virus by host (GO:0002230)positive regulation of defense response to virus by host (GO:0002230)positive regulation of defense response to virus by host (GO:0002230)positive regulation of defense response to virus by host (GO:0002230)positive regulation of type I interferon production (GO:0032481)positive regulation of type I interferon production (GO:0032481)positive regulation of type I interferon production (GO:0032481)positive regulation of type I interferon production (GO:0032481)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)site of double-strand break (GO:0035861)site of double-strand break (GO:0035861)
Expression (TPM)
CGAS — as a Regulated Gene

TFs regulating CGAS 0 TFs

Transcription factors with Perturb-seq knockdown data for CGAS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CGAS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CGAS

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CGAS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr6:73,262,731–73,263,555 189.1 kb Distal (>10kb) Multiome 460
chr6:73,314,466–73,315,532 137.3 kb Distal (>10kb) Multiome 137
chr6:73,348,234–73,349,695 102.8 kb Distal (>10kb) Multiome 281
chr6:73,388,539–73,389,752 63.3 kb Distal (>10kb) Multiome 579
chr6:73,450,878–73,452,652 229 bp At TSS Multiome 510
chr6:73,461,207–73,462,355 9.4 kb Proximal (<10kb) Multiome 806
chr6:73,511,142–73,516,574 62.0 kb Distal (>10kb) Multiome 913
chr6:73,520,105–73,522,117 69.0 kb Distal (>10kb) Multiome 1220
chr6:73,579,484–73,580,917 128.2 kb Distal (>10kb) Multiome 828
chr6:73,653,023–73,654,818 201.7 kb Distal (>10kb) Multiome 944
chr6:73,695,662–73,696,526 243.8 kb Distal (>10kb) Multiome 534
chr6:75,396,170–75,397,131 1944.3 kb Distal (>10kb) Multiome HiCAR 169

Genome Browser

Genomic view of the CGAS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr6:73,252,731 – 75,407,131
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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