Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within several processes, including cell adhesion; negative regulation of fibroblast apoptotic process; and regulation of cell shape. Predicted to be located in kinetochore. Predicted to be part of Swr1 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CFDP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CFDP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CFDP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:75,148,292–75,149,298 | 284.8 kb | Distal (>10kb) Multiome | 970 | |
| chr16:75,250,387–75,252,500 | 181.8 kb | Distal (>10kb) Multiome | 811 | |
| chr16:75,265,114–75,266,526 | 167.4 kb | Distal (>10kb) Multiome | 798 | |
| chr16:75,424,129–75,424,699 | 8.8 kb | Proximal (<10kb) | 189 | |
| chr16:75,432,825–75,434,426 | 69 bp | At TSS Multiome | 1143 | |
| chr16:75,463,598–75,465,197 | 31.2 kb | Distal (>10kb) Multiome | 999 | |
| chr16:75,494,705–75,495,929 | 62.0 kb | Distal (>10kb) Multiome | 341 | |
| chr16:75,516,521–75,518,019 | 83.9 kb | Distal (>10kb) Multiome | 921 | |
| chr16:75,555,188–75,556,662 | 121.8 kb | Distal (>10kb) Multiome | 900 | |
| chr16:75,565,779–75,567,123 | 132.8 kb | Distal (>10kb) Multiome | 834 | |
| chr16:75,593,861–75,594,383 | 160.7 kb | Distal (>10kb) Multiome | 336 | |
| chr16:75,622,804–75,623,690 | 189.8 kb | Distal (>10kb) Multiome | 852 | |
| chr16:75,647,337–75,649,003 | 215.4 kb | Distal (>10kb) Multiome | 1002 | |
| chr16:77,190,160–77,191,630 | 1757.3 kb | Distal (>10kb) Multiome HiCAR | 915 | |
| chr16:77,372,736–77,373,414 | 1939.5 kb | Distal (>10kb) Multiome HiCAR | 34 |
Genomic view of the CFDP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.