TFs regulating CFAP97 0 TFs

Transcription factors with Perturb-seq knockdown data for CFAP97. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CFAP97 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CFAP97

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CFAP97, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr4:184,983,798–184,984,312	219.9 kb	Distal (>10kb) Multiome	307
chr4:185,004,689–185,005,528	198.8 kb	Distal (>10kb) Multiome	348
chr4:185,018,062–185,018,650	185.5 kb	Distal (>10kb) Multiome	181
chr4:185,115,806–185,116,379	87.9 kb	Distal (>10kb) Multiome	365
chr4:185,127,221–185,129,177	76.4 kb	Distal (>10kb) Multiome	406
chr4:185,142,664–185,143,838	60.8 kb	Distal (>10kb) Multiome	886
chr4:185,203,468–185,204,322	9 bp	At TSS Multiome	710
chr4:185,209,029–185,211,342	5.5 kb	Proximal (<10kb) Multiome	699
chr4:185,212,760–185,213,271	8.8 kb	Proximal (<10kb)	36
chr4:185,235,783–185,236,350	32.0 kb	Distal (>10kb) Multiome	289
chr4:185,318,614–185,319,089	114.9 kb	Distal (>10kb) Multiome	382
chr4:185,395,863–185,397,395	192.6 kb	Distal (>10kb) Multiome	1140
chr4:185,425,371–185,426,547	222.1 kb	Distal (>10kb) Multiome	873
chr4:185,470,476–185,472,157	267.4 kb	Distal (>10kb) Multiome	628

Genome Browser

Genomic view of the CFAP97 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.