Involved in axonemal central apparatus assembly and spermatogenesis. Predicted to be located in motile cilium and radial spoke stalk. Implicated in spermatogenic failure 51. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CFAP91. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CFAP91 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CFAP91, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:119,463,124–119,464,243 | 239.4 kb | Distal (>10kb) Multiome | 902 | |
| chr3:119,468,550–119,469,486 | 234.1 kb | Distal (>10kb) Multiome | 832 | |
| chr3:119,497,916–119,499,024 | 204.5 kb | Distal (>10kb) Multiome | 886 | |
| chr3:119,579,336–119,580,732 | 123.2 kb | Distal (>10kb) Multiome | 519 | |
| chr3:119,676,820–119,677,853 | 25.6 kb | Distal (>10kb) Multiome | 778 | |
| chr3:119,702,500–119,703,521 | 85 bp | At TSS Multiome | 399 |
Genomic view of the CFAP91 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.