Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CFAP77. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CFAP77 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CFAP77, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:132,239,978–132,242,316 | 168.9 kb | Distal (>10kb) Multiome | 555 | |
| chr9:132,259,091–132,259,539 | 150.8 kb | Distal (>10kb) Multiome | 443 | |
| chr9:132,354,395–132,355,656 | 55.1 kb | Distal (>10kb) Multiome | 895 | |
| chr9:132,406,761–132,407,013 | 3.2 kb | Proximal (<10kb) | 512 | |
| chr9:132,407,308–132,407,509 | 2.7 kb | Proximal (<10kb) | 30 | |
| chr9:132,409,879–132,410,471 | 172 bp | At TSS Multiome | 293 | |
| chr9:132,411,065–132,411,553 | 1.1 kb | Proximal (<10kb) Multiome | 342 | |
| chr9:132,412,208–132,412,387 | 2.0 kb | Proximal (<10kb) | 109 | |
| chr9:132,582,095–132,582,589 | 172.0 kb | Distal (>10kb) Multiome HiCAR | 938 | |
| chr9:132,669,401–132,670,935 | 260.1 kb | Distal (>10kb) Multiome | 1040 | |
| chr9:132,794,730–132,795,358 | 384.7 kb | Distal (>10kb) Multiome HiCAR | 159 |
Genomic view of the CFAP77 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.