Predicted to be involved in cilium assembly and cilium movement. Predicted to act upstream of or within several processes, including maintenance of cell number; single fertilization; and spermatid development. Located in ciliary basal body and sperm flagellum. Part of outer dynein arm. Implicated in spermatogenic failure 41. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CFAP70. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CFAP70 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CFAP70, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:73,095,866–73,097,537 | 261.8 kb | Distal (>10kb) Multiome | 1042 | |
| chr10:73,167,766–73,168,681 | 190.6 kb | Distal (>10kb) Multiome | 879 | |
| chr10:73,246,675–73,247,516 | 111.6 kb | Distal (>10kb) Multiome | 1023 | |
| chr10:73,252,167–73,253,067 | 106.1 kb | Distal (>10kb) Multiome | 929 | |
| chr10:73,358,383–73,358,977 | 7 bp | At TSS Multiome | 468 | |
| chr10:73,413,302–73,414,453 | 55.3 kb | Distal (>10kb) Multiome | 938 | |
| chr10:73,495,235–73,496,398 | 137.2 kb | Distal (>10kb) Multiome | 908 | |
| chr10:73,591,236–73,591,781 | 232.7 kb | Distal (>10kb) Multiome | 359 | |
| chr10:73,591,961–73,592,227 | 233.3 kb | Distal (>10kb) Multiome | 458 | |
| chr10:73,625,111–73,626,369 | 267.2 kb | Distal (>10kb) Multiome | 810 | |
| chr10:73,647,157–73,648,042 | 288.8 kb | Distal (>10kb) Multiome | 238 |
Genomic view of the CFAP70 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.