Acts upstream of or within sperm axoneme assembly. Located in cytoplasm and sperm midpiece. Implicated in spermatogenic failure 24. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CFAP69. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CFAP69 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CFAP69, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:90,153,881–90,154,994 | 90.7 kb | Distal (>10kb) Multiome HiCAR | 605 | |
| chr7:90,210,927–90,212,730 | 33.5 kb | Distal (>10kb) Multiome | 843 | |
| chr7:90,223,993–90,224,776 | 20.8 kb | Distal (>10kb) Multiome | 109 | |
| chr7:90,244,257–90,246,748 | 25 bp | At TSS Multiome | 850 | |
| chr7:90,345,490–90,347,070 | 101.5 kb | Distal (>10kb) Multiome | 940 | |
| chr7:90,403,221–90,404,177 | 158.5 kb | Distal (>10kb) Multiome | 843 |
Genomic view of the CFAP69 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.