The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for CETN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CETN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CETN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:88,674,048–88,676,457 | 1733.7 kb | Distal (>10kb) Multiome HiCAR | 679 | |
| chr5:88,690,452–88,691,491 | 1718.7 kb | Distal (>10kb) Multiome HiCAR | 454 | |
| chr5:90,408,713–90,410,622 | 135 bp | At TSS Multiome | 999 | |
| chr5:90,473,267–90,475,425 | 65.0 kb | Distal (>10kb) Multiome | 1125 | |
| chr5:90,476,971–90,477,623 | 67.5 kb | Distal (>10kb) Multiome | 165 | |
| chr5:90,528,730–90,530,341 | 120.0 kb | Distal (>10kb) Multiome | 946 | |
| chr5:90,557,815–90,559,398 | 149.0 kb | Distal (>10kb) Multiome | 611 |
Genomic view of the CETN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.