This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Transcription factors with Perturb-seq knockdown data for CES2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CES2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CES2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:66,695,775–66,697,411 | 237.6 kb | Distal (>10kb) Multiome | 714 | |
| chr16:66,751,110–66,752,176 | 182.7 kb | Distal (>10kb) Multiome | 734 | |
| chr16:66,830,425–66,831,324 | 103.6 kb | Distal (>10kb) Multiome | 934 | |
| chr16:66,844,097–66,844,861 | 90.0 kb | Distal (>10kb) Multiome | 211 | |
| chr16:66,872,965–66,873,714 | 61.2 kb | Distal (>10kb) Multiome | 836 | |
| chr16:66,880,003–66,881,270 | 54.0 kb | Distal (>10kb) Multiome | 1020 | |
| chr16:66,924,739–66,925,515 | 9.4 kb | Proximal (<10kb) Multiome | 395 | |
| chr16:66,933,957–66,934,849 | 30 bp | At TSS Multiome | 931 | |
| chr16:67,000,412–67,001,423 | 66.6 kb | Distal (>10kb) Multiome | 270 | |
| chr16:67,013,778–67,014,584 | 79.6 kb | Distal (>10kb) Multiome | 594 | |
| chr16:67,017,916–67,018,379 | 83.6 kb | Distal (>10kb) Multiome | 530 | |
| chr16:67,028,567–67,029,938 | 94.6 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:67,109,102–67,110,434 | 175.4 kb | Distal (>10kb) Multiome | 895 | |
| chr16:67,149,282–67,151,406 | 216.3 kb | Distal (>10kb) Multiome | 693 | |
| chr16:67,154,687–67,155,820 | 221.0 kb | Distal (>10kb) Multiome | 593 | |
| chr16:67,160,628–67,161,206 | 226.6 kb | Distal (>10kb) Multiome | 524 | |
| chr16:67,162,969–67,163,815 | 228.9 kb | Distal (>10kb) Multiome | 238 | |
| chr16:67,169,105–67,171,287 | 235.1 kb | Distal (>10kb) Multiome | 813 | |
| chr16:67,173,849–67,174,861 | 239.8 kb | Distal (>10kb) Multiome | 809 | |
| chr16:67,177,863–67,178,664 | 243.8 kb | Distal (>10kb) Multiome | 544 | |
| chr16:67,183,333–67,184,856 | 249.4 kb | Distal (>10kb) Multiome HiCAR | 886 | |
| chr16:67,185,256–67,185,693 | 251.1 kb | Distal (>10kb) Multiome HiCAR | 740 | |
| chr16:67,191,949–67,192,449 | 257.7 kb | Distal (>10kb) Multiome | 781 | |
| chr16:67,198,940–67,200,211 | 265.2 kb | Distal (>10kb) Multiome | 325 | |
| chr16:67,226,487–67,227,575 | 292.5 kb | Distal (>10kb) Multiome | 909 |
Genomic view of the CES2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.