This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CERS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CERS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CERS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:150,696,984–150,697,716 | 277.7 kb | Distal (>10kb) Multiome | 619 | |
| chr1:150,875,863–150,877,222 | 98.3 kb | Distal (>10kb) Multiome | 912 | |
| chr1:150,925,543–150,926,754 | 48.7 kb | Distal (>10kb) Multiome | 813 | |
| chr1:150,973,876–150,975,458 | 148 bp | At TSS Multiome | 590 | |
| chr1:150,979,331–150,979,990 | 4.6 kb | Proximal (<10kb) Multiome | 562 | |
| chr1:150,981,212–150,981,672 | 6.4 kb | Proximal (<10kb) Multiome | 379 | |
| chr1:151,006,389–151,007,024 | 31.8 kb | Distal (>10kb) Multiome | 496 | |
| chr1:151,008,116–151,008,852 | 33.4 kb | Distal (>10kb) Multiome | 763 | |
| chr1:151,047,405–151,048,764 | 73.6 kb | Distal (>10kb) Multiome | 714 | |
| chr1:151,059,187–151,059,842 | 84.6 kb | Distal (>10kb) Multiome | 821 | |
| chr1:151,060,204–151,060,723 | 85.5 kb | Distal (>10kb) Multiome | 346 | |
| chr1:151,070,369–151,071,463 | 96.1 kb | Distal (>10kb) Multiome | 835 | |
| chr1:151,131,105–151,132,256 | 156.4 kb | Distal (>10kb) Multiome | 247 | |
| chr1:151,145,115–151,147,333 | 171.8 kb | Distal (>10kb) Multiome | 709 | |
| chr1:151,165,133–151,166,350 | 190.9 kb | Distal (>10kb) Multiome | 940 | |
| chr1:151,189,687–151,190,378 | 215.2 kb | Distal (>10kb) Multiome | 875 | |
| chr1:151,198,185–151,199,073 | 223.5 kb | Distal (>10kb) Multiome | 721 | |
| chr1:151,254,421–151,255,083 | 279.7 kb | Distal (>10kb) Multiome | 770 |
Genomic view of the CERS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.