Transcription factors with Perturb-seq knockdown data for CEROX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEROX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEROX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:683,618–684,859 | 297.2 kb | Distal (>10kb) Multiome | 701 | |
| chr16:694,897–695,485 | 286.2 kb | Distal (>10kb) Multiome | 390 | |
| chr16:705,242–706,468 | 275.6 kb | Distal (>10kb) Multiome | 248 | |
| chr16:714,577–716,048 | 266.5 kb | Distal (>10kb) Multiome | 555 | |
| chr16:720,434–721,963 | 260.3 kb | Distal (>10kb) Multiome | 966 | |
| chr16:726,310–729,144 | 254.6 kb | Distal (>10kb) Multiome | 736 | |
| chr16:740,359–741,596 | 240.5 kb | Distal (>10kb) Multiome | 897 | |
| chr16:787,564–789,160 | 193.1 kb | Distal (>10kb) Multiome | 635 | |
| chr16:807,352–808,044 | 173.8 kb | Distal (>10kb) Multiome | 600 | |
| chr16:813,330–813,960 | 167.8 kb | Distal (>10kb) Multiome | 325 | |
| chr16:970,016–971,733 | 10.6 kb | Distal (>10kb) Multiome | 800 | |
| chr16:980,014–982,920 | 184 bp | At TSS Multiome | 499 | |
| chr16:1,048,353–1,048,991 | 67.0 kb | Distal (>10kb) Multiome | 220 | |
| chr16:1,088,257–1,088,904 | 107.0 kb | Distal (>10kb) Multiome | 201 | |
| chr16:1,102,896–1,103,532 | 121.5 kb | Distal (>10kb) Multiome | 331 | |
| chr16:1,152,124–1,154,512 | 171.3 kb | Distal (>10kb) Multiome | 341 |
Genomic view of the CEROX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.