This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for CEP76. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP76 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP76, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:12,407,513–12,408,521 | 294.8 kb | Distal (>10kb) Multiome | 637 | |
| chr18:12,419,774–12,420,625 | 282.5 kb | Distal (>10kb) Multiome | 579 | |
| chr18:12,420,869–12,421,324 | 281.6 kb | Distal (>10kb) Multiome | 417 | |
| chr18:12,657,070–12,658,817 | 44.6 kb | Distal (>10kb) Multiome | 689 | |
| chr18:12,702,219–12,703,287 | 81 bp | At TSS Multiome | 869 | |
| chr18:12,766,645–12,767,371 | 64.4 kb | Distal (>10kb) Multiome | 392 | |
| chr18:12,776,564–12,778,096 | 74.3 kb | Distal (>10kb) Multiome | 123 | |
| chr18:12,862,247–12,862,768 | 159.9 kb | Distal (>10kb) Multiome | 116 | |
| chr18:12,883,233–12,884,627 | 181.4 kb | Distal (>10kb) Multiome | 904 | |
| chr18:12,946,945–12,948,745 | 245.2 kb | Distal (>10kb) Multiome | 1139 | |
| chr18:12,989,036–12,990,533 | 286.7 kb | Distal (>10kb) Multiome | 336 | |
| chr18:12,990,680–12,991,971 | 288.6 kb | Distal (>10kb) Multiome | 977 |
Genomic view of the CEP76 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.