This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CEP63. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP63 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP63, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:134,250,095–134,251,199 | 234.9 kb | Distal (>10kb) Multiome | 719 | |
| chr3:134,308,427–134,308,921 | 177.1 kb | Distal (>10kb) Multiome HiCAR | 478 | |
| chr3:134,312,827–134,313,997 | 172.3 kb | Distal (>10kb) Multiome HiCAR | 368 | |
| chr3:134,333,562–134,334,597 | 151.9 kb | Distal (>10kb) Multiome | 224 | |
| chr3:134,363,600–134,365,141 | 121.4 kb | Distal (>10kb) Multiome HiCAR | 492 | |
| chr3:134,372,925–134,375,830 | 111.1 kb | Distal (>10kb) Multiome HiCAR | 1010 | |
| chr3:134,406,305–134,407,815 | 78.9 kb | Distal (>10kb) Multiome | 295 | |
| chr3:134,485,113–134,486,743 | 310 bp | At TSS Multiome | 1009 | |
| chr3:134,600,919–134,601,384 | 115.3 kb | Distal (>10kb) Multiome | 224 | |
| chr3:134,640,811–134,642,504 | 156.1 kb | Distal (>10kb) Multiome | 257 | |
| chr3:134,650,423–134,651,401 | 165.3 kb | Distal (>10kb) Multiome | 242 |
Genomic view of the CEP63 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.