Involved in cilium assembly; cytoplasmic microtubule organization; and mitotic spindle organization. Located in centrosome; ciliary base; and midbody. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CEP126. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP126 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP126, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:101,914,433–101,915,676 | 65 bp | At TSS Multiome | 805 | |
| chr11:101,915,832–101,916,010 | 821 bp | At TSS | 75 | |
| chr11:102,047,223–102,047,965 | 132.5 kb | Distal (>10kb) Multiome | 355 | |
| chr11:102,109,725–102,112,204 | 196.6 kb | Distal (>10kb) Multiome | 1075 | |
| chr11:102,197,552–102,198,107 | 282.9 kb | Distal (>10kb) Multiome | 171 |
Genomic view of the CEP126 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.