This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for CENPS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CENPS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CENPS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:10,209,800–10,211,585 | 220.0 kb | Distal (>10kb) Multiome | 934 | |
| chr1:10,398,334–10,400,006 | 31.4 kb | Distal (>10kb) Multiome | 1064 | |
| chr1:10,430,062–10,431,244 | 186 bp | At TSS Multiome | 1007 | |
| chr1:10,472,017–10,472,900 | 42.1 kb | Distal (>10kb) Multiome | 872 | |
| chr1:10,474,760–10,475,474 | 44.6 kb | Distal (>10kb) Multiome | 744 | |
| chr1:10,638,357–10,639,497 | 208.7 kb | Distal (>10kb) Multiome | 126 | |
| chr1:10,679,481–10,679,929 | 249.4 kb | Distal (>10kb) Multiome | 463 | |
| chr1:10,693,857–10,695,287 | 264.3 kb | Distal (>10kb) Multiome | 382 | |
| chr1:10,704,382–10,704,894 | 274.2 kb | Distal (>10kb) Multiome | 393 |
Genomic view of the CENPS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.