The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CELSR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CELSR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CELSR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:108,963,024–108,963,620 | 286.2 kb | Distal (>10kb) Multiome | 906 | |
| chr1:109,041,106–109,042,646 | 207.4 kb | Distal (>10kb) Multiome | 792 | |
| chr1:109,075,733–109,076,324 | 173.5 kb | Distal (>10kb) Multiome | 864 | |
| chr1:109,090,360–109,091,274 | 158.7 kb | Distal (>10kb) Multiome | 1016 | |
| chr1:109,099,660–109,100,771 | 149.4 kb | Distal (>10kb) Multiome | 1149 | |
| chr1:109,112,499–109,113,189 | 136.7 kb | Distal (>10kb) Multiome | 536 | |
| chr1:109,113,744–109,114,449 | 135.3 kb | Distal (>10kb) Multiome | 236 | |
| chr1:109,213,499–109,214,619 | 35.7 kb | Distal (>10kb) Multiome | 770 | |
| chr1:109,229,475–109,230,215 | 19.6 kb | Distal (>10kb) Multiome | 221 | |
| chr1:109,239,452–109,239,804 | 9.7 kb | Proximal (<10kb) | 310 | |
| chr1:109,240,604–109,241,116 | 8.5 kb | Proximal (<10kb) Multiome | 391 | |
| chr1:109,249,055–109,250,364 | 24 bp | At TSS Multiome | 527 | |
| chr1:109,263,250–109,264,042 | 14.2 kb | Distal (>10kb) Multiome | 767 | |
| chr1:109,282,693–109,283,858 | 33.7 kb | Distal (>10kb) Multiome | 850 | |
| chr1:109,397,369–109,398,671 | 148.5 kb | Distal (>10kb) Multiome | 654 | |
| chr1:109,425,842–109,427,054 | 177.0 kb | Distal (>10kb) Multiome | 922 | |
| chr1:109,466,294–109,467,385 | 217.1 kb | Distal (>10kb) Multiome | 452 | |
| chr1:109,483,147–109,484,806 | 234.4 kb | Distal (>10kb) Multiome | 1031 | |
| chr1:109,493,695–109,494,597 | 244.6 kb | Distal (>10kb) Multiome | 842 | |
| chr1:109,498,180–109,498,608 | 248.9 kb | Distal (>10kb) Multiome | 178 | |
| chr1:109,509,196–109,510,011 | 260.1 kb | Distal (>10kb) Multiome | 448 | |
| chr1:109,532,157–109,533,159 | 283.2 kb | Distal (>10kb) Multiome | 517 | |
| chr1:109,548,385–109,549,096 | 299.1 kb | Distal (>10kb) Multiome | 855 |
Genomic view of the CELSR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.