Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CELF4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CELF4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CELF4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:37,217,989–37,218,718 | 267.2 kb | Distal (>10kb) Multiome | 102 | |
| chr18:37,253,050–37,254,954 | 231.5 kb | Distal (>10kb) Multiome | 323 | |
| chr18:37,361,283–37,362,734 | 123.3 kb | Distal (>10kb) Multiome | 310 | |
| chr18:37,393,894–37,394,814 | 91.4 kb | Distal (>10kb) Multiome | 385 | |
| chr18:37,476,262–37,476,668 | 8.9 kb | Proximal (<10kb) | 105 | |
| chr18:37,483,662–37,484,718 | 857 bp | At TSS | 133 | |
| chr18:37,484,881–37,486,081 | 49 bp | At TSS Multiome | 288 | |
| chr18:37,524,328–37,525,528 | 39.3 kb | Distal (>10kb) Multiome HiCAR | 228 | |
| chr18:37,537,761–37,539,124 | 52.5 kb | Distal (>10kb) Multiome HiCAR | 249 | |
| chr18:37,564,843–37,566,598 | 80.6 kb | Distal (>10kb) Multiome | 375 | |
| chr18:37,576,881–37,578,622 | 91.7 kb | Distal (>10kb) Multiome | 202 | |
| chr18:37,668,742–37,669,769 | 183.6 kb | Distal (>10kb) Multiome | 197 |
Genomic view of the CELF4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.