Enables cysteine dioxygenase activity; ferrous iron binding activity; and zinc ion binding activity. Predicted to be involved in L-cysteine catabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CDO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:115,543,835–115,545,478 | 271.8 kb | Distal (>10kb) Multiome | 943 | |
| chr5:115,601,724–115,602,813 | 214.5 kb | Distal (>10kb) Multiome | 542 | |
| chr5:115,625,502–115,626,687 | 190.6 kb | Distal (>10kb) Multiome | 976 | |
| chr5:115,785,567–115,786,155 | 30.9 kb | Distal (>10kb) Multiome | 90 | |
| chr5:115,815,539–115,817,207 | 48 bp | At TSS Multiome | 490 | |
| chr5:115,840,887–115,842,729 | 25.2 kb | Distal (>10kb) Multiome | 1077 | |
| chr5:116,084,169–116,085,557 | 268.4 kb | Distal (>10kb) Multiome | 922 |
Genomic view of the CDO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.