CDK3

cyclin dependent kinase 3

This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]

Biological processes 20 terms

ATP binding (GO:0005524)DNA damage response (GO:0006974)G0 to G1 transition (GO:0045023)G0 to G1 transition (GO:0045023)G1/S transition of mitotic cell cycle (GO:0000082)G2/M transition of mitotic cell cycle (GO:0000086)cell population proliferation (GO:0008283)cyclin-dependent protein kinase holoenzyme complex (GO:0000307)cyclin-dependent protein kinase holoenzyme complex (GO:0000307)cyclin-dependent protein serine/threonine kinase activity (GO:0004693)cyclin-dependent protein serine/threonine kinase activity (GO:0004693)cyclin-dependent protein serine/threonine kinase activity (GO:0004693)cytoplasm (GO:0005737)negative regulation of Notch signaling pathway (GO:0045746)nucleus (GO:0005634)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein serine kinase activity (GO:0106310)regulation of cell cycle (GO:0051726)signal transduction (GO:0007165)

Expression (TPM)

TFs regulating CDK3 0 TFs

Transcription factors with Perturb-seq knockdown data for CDK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CDK3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:75,720,933–75,721,693	279.5 kb	Distal (>10kb) Multiome	509
chr17:75,753,534–75,754,285	247.0 kb	Distal (>10kb) Multiome	699
chr17:75,764,621–75,765,674	235.7 kb	Distal (>10kb) Multiome	769
chr17:75,778,786–75,780,191	221.0 kb	Distal (>10kb) Multiome	1118
chr17:75,784,060–75,785,640	216.0 kb	Distal (>10kb) Multiome	1176
chr17:75,827,420–75,828,293	173.0 kb	Distal (>10kb) Multiome	404
chr17:75,830,158–75,830,695	170.5 kb	Distal (>10kb) Multiome	190
chr17:75,832,912–75,833,396	167.7 kb	Distal (>10kb) Multiome	104
chr17:75,845,103–75,845,662	155.5 kb	Distal (>10kb) Multiome	703
chr17:75,854,955–75,856,363	145.3 kb	Distal (>10kb) Multiome	1038
chr17:75,877,486–75,878,900	122.8 kb	Distal (>10kb) Multiome	884
chr17:75,896,392–75,897,754	103.9 kb	Distal (>10kb) Multiome	831
chr17:75,904,371–75,905,532	95.8 kb	Distal (>10kb) Multiome HiCAR	1045
chr17:75,940,734–75,941,471	59.7 kb	Distal (>10kb) Multiome	982
chr17:75,978,646–75,980,102	21.5 kb	Distal (>10kb) Multiome	1090
chr17:75,983,292–75,984,226	17.0 kb	Distal (>10kb) Multiome	236
chr17:76,000,481–76,000,709	145 bp	At TSS	379
chr17:76,005,683–76,005,862	4.8 kb	Proximal (<10kb)	367
chr17:76,014,120–76,014,727	13.6 kb	Distal (>10kb) Multiome	489
chr17:76,029,331–76,030,158	28.8 kb	Distal (>10kb) Multiome	722
chr17:76,072,173–76,072,853	71.7 kb	Distal (>10kb) Multiome	893
chr17:76,103,272–76,104,343	102.9 kb	Distal (>10kb) Multiome	798
chr17:76,121,142–76,122,265	120.7 kb	Distal (>10kb) Multiome	689
chr17:76,132,004–76,133,216	131.9 kb	Distal (>10kb) Multiome	536
chr17:76,141,012–76,141,958	140.5 kb	Distal (>10kb) Multiome	616
chr17:76,240,278–76,241,169	239.8 kb	Distal (>10kb) Multiome	560
chr17:76,264,834–76,266,286	264.3 kb	Distal (>10kb) Multiome	868

Genome Browser

Genomic view of the CDK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.