The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Transcription factors with Perturb-seq knockdown data for CDK10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDK10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDK10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:89,473,854–89,474,466 | 212.5 kb | Distal (>10kb) Multiome | 213 | |
| chr16:89,489,154–89,489,850 | 197.4 kb | Distal (>10kb) Multiome | 596 | |
| chr16:89,490,254–89,491,281 | 195.9 kb | Distal (>10kb) Multiome | 817 | |
| chr16:89,507,395–89,509,159 | 178.4 kb | Distal (>10kb) Multiome | 987 | |
| chr16:89,560,298–89,561,204 | 126.0 kb | Distal (>10kb) Multiome HiCAR | 1030 | |
| chr16:89,564,633–89,566,356 | 120.8 kb | Distal (>10kb) Multiome HiCAR | 894 | |
| chr16:89,574,359–89,574,949 | 111.9 kb | Distal (>10kb) Multiome HiCAR | 373 | |
| chr16:89,657,432–89,658,521 | 28.9 kb | Distal (>10kb) Multiome | 859 | |
| chr16:89,686,359–89,687,641 | 104 bp | At TSS Multiome | 1006 | |
| chr16:89,699,933–89,702,566 | 15.3 kb | Distal (>10kb) Multiome | 1079 | |
| chr16:89,711,278–89,712,334 | 25.1 kb | Distal (>10kb) Multiome | 443 | |
| chr16:89,720,440–89,722,486 | 34.7 kb | Distal (>10kb) Multiome | 1048 | |
| chr16:89,816,022–89,817,100 | 130.1 kb | Distal (>10kb) Multiome | 995 | |
| chr16:89,827,667–89,829,190 | 141.8 kb | Distal (>10kb) Multiome | 784 | |
| chr16:89,872,618–89,874,723 | 187.5 kb | Distal (>10kb) Multiome | 1046 | |
| chr16:89,917,809–89,919,023 | 231.9 kb | Distal (>10kb) Multiome | 986 | |
| chr16:89,921,530–89,925,204 | 236.5 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:89,925,437–89,926,738 | 239.6 kb | Distal (>10kb) Multiome | 654 | |
| chr16:89,972,039–89,973,313 | 286.0 kb | Distal (>10kb) Multiome | 965 |
Genomic view of the CDK10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.