Predicted to enable zinc ion binding activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in cytoplasmic side of late endosome membrane; cytoplasmic side of lysosomal membrane; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CDIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:4,244,460–4,244,980 | 294.1 kb | Distal (>10kb) Multiome | 290 | |
| chr16:4,253,312–4,254,436 | 284.8 kb | Distal (>10kb) Multiome | 960 | |
| chr16:4,263,483–4,264,402 | 275.0 kb | Distal (>10kb) Multiome | 258 | |
| chr16:4,271,070–4,274,312 | 264.8 kb | Distal (>10kb) Multiome | 1130 | |
| chr16:4,293,681–4,294,322 | 244.8 kb | Distal (>10kb) Multiome | 385 | |
| chr16:4,307,236–4,308,275 | 230.9 kb | Distal (>10kb) Multiome | 635 | |
| chr16:4,309,629–4,310,195 | 228.8 kb | Distal (>10kb) Multiome | 351 | |
| chr16:4,315,041–4,316,747 | 223.0 kb | Distal (>10kb) Multiome | 520 | |
| chr16:4,327,446–4,328,634 | 210.5 kb | Distal (>10kb) Multiome | 495 | |
| chr16:4,350,579–4,351,773 | 187.4 kb | Distal (>10kb) Multiome | 674 | |
| chr16:4,371,473–4,372,791 | 167.0 kb | Distal (>10kb) Multiome | 617 | |
| chr16:4,402,485–4,403,104 | 136.0 kb | Distal (>10kb) Multiome | 450 | |
| chr16:4,415,818–4,417,201 | 122.1 kb | Distal (>10kb) Multiome | 681 | |
| chr16:4,425,392–4,426,322 | 113.1 kb | Distal (>10kb) Multiome | 881 | |
| chr16:4,474,111–4,474,929 | 64.2 kb | Distal (>10kb) Multiome | 626 | |
| chr16:4,476,027–4,477,237 | 62.4 kb | Distal (>10kb) Multiome | 841 | |
| chr16:4,537,639–4,538,998 | 120 bp | At TSS Multiome | 1087 | |
| chr16:4,585,331–4,585,992 | 46.9 kb | Distal (>10kb) Multiome | 223 | |
| chr16:4,613,912–4,617,164 | 76.1 kb | Distal (>10kb) Multiome HiCAR | 1079 | |
| chr16:4,624,301–4,625,703 | 85.9 kb | Distal (>10kb) Multiome | 866 | |
| chr16:4,693,016–4,694,663 | 154.8 kb | Distal (>10kb) Multiome | 730 | |
| chr16:4,733,836–4,735,221 | 195.7 kb | Distal (>10kb) Multiome | 858 | |
| chr16:4,766,728–4,767,628 | 228.5 kb | Distal (>10kb) Multiome | 795 | |
| chr16:4,768,438–4,769,162 | 230.0 kb | Distal (>10kb) Multiome | 677 | |
| chr16:4,801,836–4,803,175 | 263.5 kb | Distal (>10kb) Multiome | 743 |
Genomic view of the CDIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.