This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily. The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent cell-cell adhesion molecules. This protocadherin represents a new candidate for tumor suppression. Alternatively spliced transcript variants that encode the same protein have been identified. [provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for CDHR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDHR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDHR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:176,361,095–176,362,133 | 181.8 kb | Distal (>10kb) Multiome | 877 | |
| chr5:176,365,184–176,366,532 | 178.0 kb | Distal (>10kb) Multiome | 352 | |
| chr5:176,388,019–176,389,614 | 154.6 kb | Distal (>10kb) Multiome | 1052 | |
| chr5:176,415,859–176,416,971 | 126.9 kb | Distal (>10kb) Multiome HiCAR | 827 | |
| chr5:176,441,967–176,442,454 | 101.3 kb | Distal (>10kb) Multiome | 166 | |
| chr5:176,447,162–176,449,016 | 95.3 kb | Distal (>10kb) Multiome | 859 | |
| chr5:176,536,385–176,538,671 | 5.6 kb | Proximal (<10kb) Multiome | 1006 | |
| chr5:176,541,333–176,544,229 | 1.8 kb | Proximal (<10kb) Multiome | 733 | |
| chr5:176,596,638–176,597,570 | 53.5 kb | Distal (>10kb) Multiome | 234 | |
| chr5:176,609,466–176,610,727 | 66.5 kb | Distal (>10kb) Multiome HiCAR | 544 | |
| chr5:176,618,956–176,619,934 | 75.8 kb | Distal (>10kb) Multiome | 328 | |
| chr5:176,630,050–176,630,816 | 86.9 kb | Distal (>10kb) Multiome | 352 | |
| chr5:176,646,726–176,648,437 | 103.8 kb | Distal (>10kb) Multiome | 701 | |
| chr5:176,660,849–176,661,318 | 117.5 kb | Distal (>10kb) Multiome | 382 | |
| chr5:176,809,543–176,810,815 | 266.8 kb | Distal (>10kb) Multiome | 404 | |
| chr5:176,817,316–176,818,386 | 274.5 kb | Distal (>10kb) Multiome | 358 |
Genomic view of the CDHR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.