CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for CDC37L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC37L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC37L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:2,816,339–2,817,126 | 1862.8 kb | Distal (>10kb) Multiome HiCAR | 152 | |
| chr9:4,489,445–4,492,426 | 187.8 kb | Distal (>10kb) Multiome | 545 | |
| chr9:4,507,563–4,508,683 | 171.3 kb | Distal (>10kb) Multiome | 213 | |
| chr9:4,514,255–4,515,200 | 164.7 kb | Distal (>10kb) Multiome | 105 | |
| chr9:4,661,662–4,663,256 | 17.2 kb | Distal (>10kb) Multiome | 925 | |
| chr9:4,678,186–4,678,367 | 1.2 kb | Proximal (<10kb) | 237 | |
| chr9:4,678,800–4,680,345 | 23 bp | At TSS Multiome | 960 | |
| chr9:4,740,523–4,742,116 | 61.7 kb | Distal (>10kb) Multiome | 942 | |
| chr9:4,762,590–4,763,629 | 83.8 kb | Distal (>10kb) Multiome | 504 | |
| chr9:4,792,132–4,794,058 | 113.3 kb | Distal (>10kb) Multiome | 871 |
Genomic view of the CDC37L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.