The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDC37. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC37 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC37, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:10,106,123–10,106,748 | 297.2 kb | Distal (>10kb) Multiome | 842 | |
| chr19:10,113,011–10,113,478 | 290.3 kb | Distal (>10kb) Multiome | 511 | |
| chr19:10,119,464–10,120,287 | 283.6 kb | Distal (>10kb) Multiome | 818 | |
| chr19:10,194,229–10,195,372 | 208.6 kb | Distal (>10kb) Multiome | 939 | |
| chr19:10,230,671–10,231,665 | 172.2 kb | Distal (>10kb) Multiome | 595 | |
| chr19:10,251,723–10,252,663 | 151.5 kb | Distal (>10kb) Multiome | 969 | |
| chr19:10,269,513–10,270,051 | 133.9 kb | Distal (>10kb) Multiome | 523 | |
| chr19:10,270,913–10,271,370 | 132.4 kb | Distal (>10kb) Multiome | 753 | |
| chr19:10,286,849–10,287,511 | 116.5 kb | Distal (>10kb) Multiome | 621 | |
| chr19:10,288,709–10,290,833 | 114.7 kb | Distal (>10kb) Multiome | 688 | |
| chr19:10,292,085–10,293,198 | 111.1 kb | Distal (>10kb) Multiome | 441 | |
| chr19:10,315,359–10,316,478 | 87.6 kb | Distal (>10kb) Multiome | 830 | |
| chr19:10,332,816–10,334,107 | 70.0 kb | Distal (>10kb) Multiome | 882 | |
| chr19:10,334,573–10,335,642 | 68.5 kb | Distal (>10kb) Multiome | 584 | |
| chr19:10,352,359–10,354,435 | 50.9 kb | Distal (>10kb) Multiome | 447 | |
| chr19:10,380,209–10,381,218 | 22.9 kb | Distal (>10kb) Multiome | 874 | |
| chr19:10,403,282–10,404,914 | 138 bp | At TSS Multiome | 794 | |
| chr19:10,416,245–10,417,312 | 13.2 kb | Distal (>10kb) Multiome | 988 | |
| chr19:10,417,499–10,421,409 | 16.8 kb | Distal (>10kb) Multiome | 801 | |
| chr19:10,424,198–10,424,839 | 21.0 kb | Distal (>10kb) Multiome | 563 | |
| chr19:10,431,990–10,432,435 | 28.7 kb | Distal (>10kb) Multiome | 301 | |
| chr19:10,460,915–10,461,960 | 57.8 kb | Distal (>10kb) Multiome | 340 | |
| chr19:10,502,251–10,503,615 | 99.3 kb | Distal (>10kb) Multiome | 1013 | |
| chr19:10,514,009–10,514,960 | 110.9 kb | Distal (>10kb) Multiome | 172 | |
| chr19:10,517,347–10,518,104 | 114.2 kb | Distal (>10kb) Multiome | 338 | |
| chr19:10,543,499–10,544,302 | 140.3 kb | Distal (>10kb) Multiome | 617 | |
| chr19:10,565,054–10,566,439 | 162.5 kb | Distal (>10kb) Multiome | 923 | |
| chr19:10,568,225–10,569,839 | 165.5 kb | Distal (>10kb) Multiome | 871 | |
| chr19:10,602,117–10,602,945 | 198.9 kb | Distal (>10kb) Multiome | 518 | |
| chr19:10,625,339–10,625,984 | 222.0 kb | Distal (>10kb) Multiome | 451 | |
| chr19:10,653,364–10,655,129 | 250.6 kb | Distal (>10kb) Multiome | 1086 | |
| chr19:10,695,264–10,696,403 | 292.3 kb | Distal (>10kb) Multiome | 831 | |
| chr19:10,701,273–10,702,291 | 297.9 kb | Distal (>10kb) Multiome | 889 |
Genomic view of the CDC37 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.