The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for CD74. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD74 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD74, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:150,161,225–150,162,105 | 251.1 kb | Distal (>10kb) Multiome | 389 | |
| chr5:150,211,110–150,211,964 | 201.2 kb | Distal (>10kb) Multiome | 131 | |
| chr5:150,302,023–150,303,433 | 109.9 kb | Distal (>10kb) Multiome | 377 | |
| chr5:150,357,249–150,358,378 | 55.1 kb | Distal (>10kb) Multiome | 746 | |
| chr5:150,409,825–150,410,350 | 2.8 kb | Proximal (<10kb) Multiome | 299 | |
| chr5:150,410,459–150,410,847 | 1.9 kb | Proximal (<10kb) | 221 | |
| chr5:150,412,530–150,413,063 | 29 bp | At TSS Multiome | 495 | |
| chr5:150,441,289–150,442,097 | 28.9 kb | Distal (>10kb) Multiome | 188 | |
| chr5:150,449,356–150,450,212 | 37.1 kb | Distal (>10kb) Multiome | 1068 | |
| chr5:150,458,741–150,459,365 | 46.2 kb | Distal (>10kb) Multiome | 430 | |
| chr5:150,485,401–150,487,150 | 74.0 kb | Distal (>10kb) Multiome | 761 | |
| chr5:150,624,424–150,625,067 | 212.0 kb | Distal (>10kb) Multiome | 250 | |
| chr5:150,656,143–150,657,405 | 243.9 kb | Distal (>10kb) Multiome | 607 | |
| chr5:150,671,571–150,672,919 | 259.7 kb | Distal (>10kb) Multiome | 303 | |
| chr5:150,700,548–150,701,464 | 288.3 kb | Distal (>10kb) Multiome | 858 |
Genomic view of the CD74 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.