This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]
Transcription factors with Perturb-seq knockdown data for CD2BP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD2BP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD2BP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:30,063,722–30,066,296 | 291.2 kb | Distal (>10kb) Multiome | 1209 | |
| chr16:30,075,490–30,076,439 | 279.3 kb | Distal (>10kb) Multiome | 828 | |
| chr16:30,090,881–30,092,910 | 262.4 kb | Distal (>10kb) Multiome | 1101 | |
| chr16:30,095,557–30,096,839 | 259.0 kb | Distal (>10kb) Multiome | 824 | |
| chr16:30,122,728–30,123,578 | 232.0 kb | Distal (>10kb) Multiome | 718 | |
| chr16:30,182,759–30,183,865 | 171.9 kb | Distal (>10kb) Multiome | 547 | |
| chr16:30,334,526–30,335,777 | 19.9 kb | Distal (>10kb) Multiome | 486 | |
| chr16:30,354,854–30,355,978 | 116 bp | At TSS Multiome | 1070 | |
| chr16:30,369,220–30,371,611 | 15.5 kb | Distal (>10kb) Multiome | 818 | |
| chr16:30,377,495–30,379,532 | 23.1 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,394,422–30,396,098 | 39.9 kb | Distal (>10kb) Multiome | 941 | |
| chr16:30,400,026–30,401,048 | 45.3 kb | Distal (>10kb) Multiome | 839 | |
| chr16:30,406,974–30,408,429 | 52.2 kb | Distal (>10kb) Multiome | 908 | |
| chr16:30,417,414–30,418,576 | 62.8 kb | Distal (>10kb) Multiome | 543 | |
| chr16:30,429,571–30,430,773 | 74.9 kb | Distal (>10kb) Multiome | 1060 | |
| chr16:30,445,340–30,446,062 | 90.5 kb | Distal (>10kb) Multiome | 898 | |
| chr16:30,526,068–30,527,896 | 172.1 kb | Distal (>10kb) Multiome | 1004 | |
| chr16:30,534,370–30,535,460 | 179.6 kb | Distal (>10kb) Multiome | 957 | |
| chr16:30,557,913–30,558,847 | 203.2 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,571,001–30,572,505 | 216.7 kb | Distal (>10kb) Multiome | 950 | |
| chr16:30,585,243–30,586,223 | 230.5 kb | Distal (>10kb) Multiome | 588 | |
| chr16:30,609,586–30,610,748 | 255.2 kb | Distal (>10kb) Multiome | 1030 | |
| chr16:30,634,070–30,634,986 | 279.1 kb | Distal (>10kb) Multiome | 907 | |
| chr16:30,650,029–30,651,831 | 295.4 kb | Distal (>10kb) Multiome | 992 |
Genomic view of the CD2BP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.