This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for CD1D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD1D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD1D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:157,992,976–157,994,637 | 187.4 kb | Distal (>10kb) Multiome | 333 | |
| chr1:158,113,137–158,114,026 | 67.4 kb | Distal (>10kb) Multiome | 328 | |
| chr1:158,149,364–158,150,151 | 31.2 kb | Distal (>10kb) Multiome | 421 | |
| chr1:158,177,403–158,178,263 | 3.1 kb | Proximal (<10kb) Multiome | 195 | |
| chr1:158,180,618–158,181,838 | 173 bp | At TSS Multiome | 321 | |
| chr1:158,185,775–158,186,089 | 4.7 kb | Proximal (<10kb) | 62 | |
| chr1:158,999,415–159,000,347 | 818.8 kb | Distal (>10kb) Multiome HiCAR | 267 | |
| chr1:159,005,384–159,006,879 | 825.0 kb | Distal (>10kb) Multiome HiCAR | 342 |
Genomic view of the CD1D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.