Transcription factors with Perturb-seq knockdown data for CCDC7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:32,150,441–32,151,508 | 295.1 kb | Distal (>10kb) Multiome | 259 | |
| chr10:32,265,752–32,266,479 | 180.2 kb | Distal (>10kb) Multiome | 182 | |
| chr10:32,266,857–32,267,419 | 179.0 kb | Distal (>10kb) Multiome | 101 | |
| chr10:32,345,913–32,347,750 | 99.7 kb | Distal (>10kb) Multiome | 1064 | |
| chr10:32,378,318–32,378,948 | 67.3 kb | Distal (>10kb) Multiome | 583 | |
| chr10:32,379,388–32,379,855 | 66.4 kb | Distal (>10kb) Multiome | 367 | |
| chr10:32,445,625–32,446,967 | 31 bp | At TSS Multiome | 813 | |
| chr10:32,450,403–32,450,644 | 4.3 kb | Proximal (<10kb) | 4 |
Genomic view of the CCDC7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.