This gene encodes a protein containing a coiled-coil domain. The encoded protein functions in the regulation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) by interacting with COMMD (copper metabolism Murr1 domain-containing) proteins. The mouse orthologous protein has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. This human gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for CCDC22. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC22 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC22, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:48,957,469–48,959,105 | 277.2 kb | Distal (>10kb) Multiome | 722 | |
| chrX:49,001,538–49,002,676 | 233.1 kb | Distal (>10kb) Multiome | 540 | |
| chrX:49,039,840–49,040,493 | 195.4 kb | Distal (>10kb) Multiome | 436 | |
| chrX:49,042,954–49,044,182 | 191.9 kb | Distal (>10kb) Multiome | 664 | |
| chrX:49,053,328–49,054,050 | 181.8 kb | Distal (>10kb) Multiome | 403 | |
| chrX:49,071,863–49,072,612 | 163.4 kb | Distal (>10kb) Multiome | 107 | |
| chrX:49,073,903–49,074,451 | 161.4 kb | Distal (>10kb) Multiome | 464 | |
| chrX:49,100,885–49,101,855 | 134.2 kb | Distal (>10kb) Multiome | 562 | |
| chrX:49,155,633–49,156,658 | 79.3 kb | Distal (>10kb) Multiome | 524 | |
| chrX:49,163,555–49,164,377 | 71.5 kb | Distal (>10kb) Multiome | 485 | |
| chrX:49,166,140–49,166,713 | 69.0 kb | Distal (>10kb) Multiome | 416 | |
| chrX:49,184,219–49,185,254 | 50.9 kb | Distal (>10kb) Multiome | 389 | |
| chrX:49,186,113–49,186,660 | 49.0 kb | Distal (>10kb) Multiome | 589 | |
| chrX:49,190,730–49,191,899 | 44.3 kb | Distal (>10kb) Multiome | 636 | |
| chrX:49,199,793–49,200,448 | 35.3 kb | Distal (>10kb) Multiome | 806 | |
| chrX:49,230,351–49,230,685 | 4.8 kb | Proximal (<10kb) | 194 | |
| chrX:49,230,792–49,231,268 | 4.4 kb | Proximal (<10kb) Multiome | 221 | |
| chrX:49,235,343–49,235,802 | at TSS | At TSS | 470 | |
| chrX:49,268,786–49,270,236 | 33.9 kb | Distal (>10kb) Multiome | 603 |
Genomic view of the CCDC22 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.