The protein encoded by this gene contains a coiled-coil domain. Alternative splicing results in multiple transcript variants encoding different isoforms. A single nucleotide polymorphism (SNP) in this gene has been associated with increased susceptibility to Behcet's Disease (PMID: 19442274). [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for CCDC180. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC180 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC180, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:97,013,175–97,013,888 | 293.7 kb | Distal (>10kb) Multiome | 273 | |
| chr9:97,038,375–97,039,810 | 268.1 kb | Distal (>10kb) Multiome | 639 | |
| chr9:97,051,679–97,052,459 | 255.3 kb | Distal (>10kb) Multiome | 224 | |
| chr9:97,214,476–97,215,067 | 92.6 kb | Distal (>10kb) Multiome | 48 | |
| chr9:97,220,933–97,222,786 | 86.1 kb | Distal (>10kb) Multiome | 231 | |
| chr9:97,238,002–97,238,892 | 68.8 kb | Distal (>10kb) Multiome | 684 | |
| chr9:97,306,799–97,308,104 | 17 bp | At TSS Multiome | 182 | |
| chr9:97,386,832–97,387,759 | 79.9 kb | Distal (>10kb) Multiome | 555 | |
| chr9:97,411,603–97,412,682 | 104.8 kb | Distal (>10kb) Multiome | 864 | |
| chr9:97,501,163–97,503,374 | 195.6 kb | Distal (>10kb) Multiome | 581 | |
| chr9:97,528,160–97,528,802 | 221.2 kb | Distal (>10kb) Multiome | 118 |
Genomic view of the CCDC180 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.