Predicted to be involved in spermatid development. Predicted to act upstream of or within several processes, including regulation of phosphatase activity; single fertilization; and sperm flagellum assembly. Predicted to be located in sperm head-tail coupling apparatus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CCDC159. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC159 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC159, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:11,339,100–11,339,837 | 6.7 kb | Proximal (<10kb) | 506 | |
| chr19:11,346,053–11,346,958 | at TSS | At TSS | 676 | |
| chr19:11,355,078–11,355,735 | 8.5 kb | Proximal (<10kb) | 382 |
Genomic view of the CCDC159 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.