This gene encodes a member of a family of cation channel proteins that localize to the flagellum of spermatozoa. Defects at this locus causes male infertility. Alternatively spliced transcript variants have been observed at this locus. Readthrough transcription originates upstream of this locus in diphosphoinositol pentakisphosphate kinase 1 pseudogene 1 and is represented by GeneID:110006325. Related pseudogenes are found next to this locus on chromosome 15 and on chromosome 5. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for CATSPER2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CATSPER2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CATSPER2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:43,370,765–43,371,726 | 277.6 kb | Distal (>10kb) Multiome | 774 | |
| chr15:43,492,673–43,493,432 | 155.7 kb | Distal (>10kb) Multiome | 544 | |
| chr15:43,510,550–43,511,326 | 138.0 kb | Distal (>10kb) Multiome | 683 | |
| chr15:43,746,005–43,746,833 | 97.5 kb | Distal (>10kb) Multiome | 588 | |
| chr15:43,776,241–43,777,647 | 128.3 kb | Distal (>10kb) Multiome | 761 | |
| chr15:43,791,747–43,792,642 | 143.3 kb | Distal (>10kb) Multiome | 821 |
Genomic view of the CATSPER2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.