Enables chromatin-protein adaptor activity and promoter-enhancer loop anchoring activity. Involved in chromatin looping and positive regulation of transcription by RNA polymerase II. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CASC11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CASC11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CASC11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:127,732,588–127,733,103 | 5.9 kb | Proximal (<10kb) | 122 | |
| chr8:127,733,783–127,736,880 | 2.1 kb | Proximal (<10kb) | 1123 | |
| chr8:127,736,970–127,739,571 | at TSS | At TSS | 736 | |
| chr8:127,741,622–127,741,928 | 2.6 kb | Proximal (<10kb) | 421 | |
| chr8:127,742,787–127,743,497 | 3.8 kb | Proximal (<10kb) | 428 |
Genomic view of the CASC11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.