This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for CARM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CARM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CARM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:10,602,117–10,602,945 | 269.1 kb | Distal (>10kb) Multiome | 518 | |
| chr19:10,625,339–10,625,984 | 246.0 kb | Distal (>10kb) Multiome | 451 | |
| chr19:10,653,364–10,655,129 | 217.4 kb | Distal (>10kb) Multiome | 1086 | |
| chr19:10,695,264–10,696,403 | 175.7 kb | Distal (>10kb) Multiome | 831 | |
| chr19:10,701,273–10,702,291 | 170.1 kb | Distal (>10kb) Multiome | 889 | |
| chr19:10,717,121–10,718,717 | 153.8 kb | Distal (>10kb) Multiome | 849 | |
| chr19:10,835,171–10,836,835 | 35.6 kb | Distal (>10kb) Multiome | 1096 | |
| chr19:10,864,493–10,864,696 | 6.9 kb | Proximal (<10kb) | 377 | |
| chr19:10,870,403–10,872,620 | 390 bp | At TSS Multiome | 714 | |
| chr19:10,879,057–10,879,417 | 7.5 kb | Proximal (<10kb) | 501 | |
| chr19:10,928,331–10,929,395 | 57.2 kb | Distal (>10kb) Multiome | 860 | |
| chr19:10,960,232–10,961,863 | 89.3 kb | Distal (>10kb) Multiome | 1016 | |
| chr19:11,089,041–11,091,015 | 217.7 kb | Distal (>10kb) Multiome | 964 | |
| chr19:11,137,551–11,138,233 | 266.4 kb | Distal (>10kb) Multiome | 584 | |
| chr19:11,155,520–11,156,298 | 284.3 kb | Distal (>10kb) Multiome | 754 |
Genomic view of the CARM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.